Joglekar, MV and Kunte, PS and Wong, WKM and Bhat, DS and Satoor, SN and Patil, RR and Karandikar, MS and Fall, CHD and Yajnik, CS and Hardikar, AA (2022) Circulating microRNAs from early childhood and adolescence are associated with pre-diabetes at 18 years of age in women from the PMNS cohort. Journal of Developmental Origins of Health and Disease .

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Abstract

With type 2 diabetes presenting at younger ages, there is a growing need to identify biomarkers of future glucose intolerance. A high (20%) prevalence of glucose intolerance at 18 years was seen in women from the Pune Maternal Nutrition Study (PMNS) birth cohort. We investigated the potential of circulating microRNAs in risk stratification for future pre-diabetes in these women. Here, we provide preliminary longitudinal analyses of circulating microRNAs in normal glucose tolerant (NGT@18y, N = 10) and glucose intolerant (N = 8) women (ADA criteria) at 6, 12 and 17 years of their age using discovery analysis (OpenArray™ platform). Machine-learning workflows involving Lasso with bootstrapping/leave-one-out cross-validation identified microRNAs associated with glucose intolerance at 18 years of age. Several microRNAs, including miR-212-3p, miR-30e-3p and miR-638, stratified glucose-intolerant women from NGT at childhood. Our results suggest that circulating microRNAs, longitudinally assessed over 17 years of life, are dynamic biomarkers associated with and predictive of pre-diabetes at 18 years of age. Validation of these findings in males and remaining participants from the PMNS birth cohort will provide a unique opportunity to study novel epigenetic mechanisms in the life-course progression of glucose intolerance and enhance current clinical risk prediction of pre-diabetes and progression to type 2 diabetes.

Item Type:	Article
Additional Information:	1. Western Sydney University, Campbelltown, NSW 2560, Australia, 2. KEM Hospital and Research Center, Rasta Peth, Pune 411001, India. 3. MRC Lifecourse Epidemiology Unit, Southampton University and General Hospital, Southampton, UK. 4. National Centre for Cell Science, , NCMR , Pune 411026, India. 5. DY Patil Medical College, DY Patil University, Pimpri, Pune, 411048. 6.
Subjects:	Diabetes
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	18 Oct 2022 07:46
Last Modified:	18 Oct 2022 07:46
URI:	http://nccs.sciencecentral.in/id/eprint/1169

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