Palazzo , AF and Joseph, J and Ming Lim , L and Thakur, KT (2022) Palazzo AF, Joseph J, Ming Lim , Thakur KT. Workshop on RanBP2/Nup358 and acute necrotizing encephalopathy. Nucleus. 2022 Dec;13(1):154-169. Nucleus, 13 (1). pp. 154-169.

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Abstract

Dominant missense mutations in RanBP2/Nup358 cause Acute Necrotizing Encephalopathy (ANE), a pediatric disease where seemingly healthy individuals develop a cytokine storm that is restricted to the central nervous system in response to viral infection. Untreated, this condition leads to seizures, coma, long-term neurological damage and a high rate of mortality. The exact mechanism by which RanBP2 mutations contribute to the development of ANE remains elusive. In November 2021, a number of clinicians and basic scientists presented their work on this disease and on the interactions between RanBP2/Nup358, viral infections, the innate immune response and other cellular processes.

Item Type:	Article
Subjects:	Cell Biology
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	21 Oct 2022 10:53
Last Modified:	21 Oct 2022 10:53
URI:	http://nccs.sciencecentral.in/id/eprint/1214

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