Kamble , M and Saadi, F and Kumar, S and Saha, B and Sarma , JD (2023) Inducible nitric oxide synthase deficiency promotes murine-β-coronavirus induced demyelination. Virology Journal, 20 (51).

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Abstract

Multiple sclerosis (MS) is characterized by neuroinflammation and demyelination orchestrated by activated neuroglial cells, CNS infiltrating leukocytes, and their reciprocal interactions through inflammatory signals. An inflammatory stimulus triggers inducible nitric oxide synthase (NOS2), a pro-inflammatory marker of microglia/macrophages (MG/Mφ) to catalyze sustained nitric oxide production. NOS2 during neuroinflammation, has been associated with MS disease pathology; however, studies dissecting its role in demyelination are limited. We studied the role of NOS2 in a recombinant β-coronavirus-MHV-RSA59 induced neuroinflammation, an experimental animal model mimicking the pathological hallmarks of MS: neuroinflammatory demyelination and axonal degeneration.

Item Type:	Article
Subjects:	Infection and Immunity
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	19 Apr 2023 11:57
Last Modified:	19 Apr 2023 11:57
URI:	http://nccs.sciencecentral.in/id/eprint/1259

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