Dhat , R and Mongad , D and Raji , S and Arkat, S and Mahapatra, NR and Singhal, N and Sitasawad , SL (2023) Epigenetic modifier alpha‑ketoglutarate modulates aberrant gene body methylation and hydroxymethylation marks in diabetic heart. Epigenetics & Chromatin, 17 (12).

Full text not available from this repository. (Request a copy)

Abstract

Diabetic cardiomyopathy (DCM) is a leading cause of death in diabetic patients. Hyperglycemic myocardial microenvironment significantly alters chromatin architecture and the transcriptome, resulting in aberrant activation of signaling pathways in a diabetic heart. Epigenetic marks play vital roles in transcriptional reprogramming during the development of DCM. The current study is aimed to profile genome-wide DNA (hydroxy)methylation patterns in the hearts of control and streptozotocin (STZ)-induced diabetic rats and decipher the effect of modulation of DNA methylation by alpha-ketoglutarate (AKG), a TET enzyme cofactor, on the progression of DCM.

Item Type:	Article
Subjects:	Cell Biology
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	26 May 2023 10:12
Last Modified:	26 May 2023 10:12
URI:	http://nccs.sciencecentral.in/id/eprint/1268

Actions (login required)

View Item