Giri , S and Lal, G (2022) Vg2+ T cells and its regulatory potential in skin allograft survival. Journal of Cellular Immunology, 4 (6). pp. 219-222. ISSN 2022 May : 4(6):219-222.

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Abstract

Our recently published research article “Vγ2+ γδ T cells in the presence of anti-CD40L control surgical inflammation and promote skin allograft survival” revealed that the Vγ2+ subset of γδ T cells, which otherwise are known primarily for its proinflammatory function, regulate the survival of skin allografts in the presence of anti-CD40L. Upon depletion of Vγ2+ γδ T cells, tolerogen DST (donor-specific transfusion) plus anti-CD40L induced skin allograft survival was significantly reduced. Tolerogen treatment increased the frequency of CD39+Vγ2+ regulatory γδ T cells and suppressed IFN-γ-producing effector Vγ2+ γδ T cells in the spleen and allograft. Tolerized Vγ2+ γδ T cells inhibited differentiation of inflammatory T helper type 1 (Th1) cells. Furthermore, the adoptive transfer of regulatory Vγ2+ γδ T cells prolonged the survival of allografts in untreated wild-type and TCRδ-/- mice. Our study highlights the critical role γδ T cells in transplant tolerance and paves the way for future research toward exploring regulatory γδ T cells.

Item Type:	Article
Subjects:	Infection and Immunity
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	08 Aug 2023 09:19
Last Modified:	08 Aug 2023 09:19
URI:	http://nccs.sciencecentral.in/id/eprint/1281

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