Kotammagari , TK and Misra, S and Paul, S and Kunte, S and Gonnade, RG and Santra, MK and Bhattacharya, AK (2023) An accelerated Rauhut-Currier dimerization enabled the synthesis of (±)-incarvilleatone and anticancer studies. Beilstein Journal of Organic Chemistry, 19. pp. 204-211.

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Abstract

The total synthesis of racemic incarvilleatone has been achieved by utilizing unexplored accelerated Rauhut–Currier (RC) dimerization. The other key steps of the synthesis are oxa-Michael and aldol reactions in a tandem sequence. Racemic incarvilleatone was separated by chiral HPLC and the configuration of each enantiomer was determined by single-crystal X-ray analysis. In addition, a one-pot synthesis of (±)-incarviditone has been achieved from rac-rengyolone by using KHMDS as a base. We have also assessed the anticancer activity of all the synthesized compounds in breast cancer cells nonetheless, they exhibited very limited growth suppression activity.

Item Type:	Article
Subjects:	Cancer Biology
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	08 Aug 2023 09:36
Last Modified:	08 Aug 2023 09:36
URI:	http://nccs.sciencecentral.in/id/eprint/1283

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