Kumar , CMS (2016) Molecular mechanism of drug resistance: common themes. In: Antibiotic Resistance. Drug Resistance in Bacteria, Fungi, Malaria, and Cancer . Springer, pp. 24-46.

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Abstract

Antibiotics are the chemical or biochemical moieties that specifically and effectively inhibit the growth of a pathogen but not the host organism and thus are employed in the treatment of the infection by the pathogen. However, the survival pressure in the presence of antimicrobial agents forces a minor fraction of the bacterial population to evolve mechanisms that evade the inhibitory effects of the administered antibiological agent, thereby emerging as a drug-resistant variety and consequently challenging the treatment regime. Additionally, the emergence of multidrug-resistant (MDR) variants of the pathogens that are capable of resisting several structurally dissimilar drugs is becoming very common and resulting in the infections that are difficult or impossible to treat. To counter the vast array of chemically and structurally dissimilar antibiotics within their lifestyle boundaries, different bacteria have developed different antibiotic- and pathogen-specific resistance mechanisms. Although distinct and involving several molecular events, these mechanisms can be broadly classified into two modes, the intrinsic and the acquired modes of resistance, which are further classified into subclasses. This chapter reviews recent advances and current understanding of the molecular details of these mechanisms.

Item Type:	Book Section
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	23 Dec 2021 10:59
Last Modified:	23 Dec 2021 10:59
URI:	http://nccs.sciencecentral.in/id/eprint/168

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