Sonar , S. and Lal , G. (2015) Role of tumor necrosis factor superfamily in neuroinflammation and autoimmunity. Frontier Immunolgy : Multiple Scierosis and Neuroimmuology. , 6 (364). pp. 1-13.

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Abstract

Tumor necrosis factor superfamily (TNFSF) molecules play an important role in the activation, proliferation, differentiation, and migration of immune cells into the central nervous system (CNS). Several TNF superfamily molecules are known to control alloimmunity, autoimmunity, and immunity. Development of transgenic and gene knockout animals, and monoclonal antibodies against TNFSF molecules have increased our understanding of individual receptor–ligand interactions, and their intracellular signaling during homeostasis and neuroinflammation. A strong clinical association has been observed between TNFSF members and CNS autoimmunity such as multiple sclerosis and also in its animal model experimental autoimmune encephalomyelitis. Therefore, they are promising targets for alternative therapeutic options to control autoimmunity. Although, TNFSF ligands are widely distributed and have diverse functions, we have restricted the discussions in this review to TNFSF receptor–ligand interactions and their role in the pathogenesis of neuroinflammation and CNS autoimmunity

Item Type:	Article
Additional Information:	This is Open Access Article to access full text click above web link
Subjects:	Infection and Immunity
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	04 Dec 2015 06:17
Last Modified:	19 Feb 2016 08:34
URI:	http://nccs.sciencecentral.in/id/eprint/204

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