Dinda, J. and Adhikary, S.D. and Roymahapatra, G. and Nakka, K.K. and Santra , M.K. (2014) Synthesis, structure, electrochemistry and cytotoxicity studies of Ru(II) and Pt(II)–N-heterocyclic carbene complexes of CNC-pincer ligand. Inorganica Chimica Acta, 413. pp. 23-31.

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Abstract

Synthesis, structure, electrochemistry and theoretical studies of Ru(II) and Pt(II) complexes bearing CNC-pincer carbene ligand [1,1′-[2,6-pyridinylbis(methylene)]bis[3-methylbenzimidazolium)bromide], 1·H2Br2 have been described. The compounds were fully characterized by elemental analysis, NMR, UV–Vis spectroscopy and finally the solid state structure of [Ru(1)2][PF6]2, 2, was confirmed by X-ray diffraction studies. The Pt(II)–NHC complex [Pt(1)Cl][PF6], 3 has been synthesized by silver-carbene transfer method and geometry was optimized theoretically. Cyclic voltammetry studies revealed Ru(II)/Ru(III) reversible oxidation couple at 0.57 V and Pt(II)/Pt(IV) couple at 0.48 V. Anticancer activities of complexes 2 and 3 have been studied upon breast (MCF7), colon (HCT116) and lung (A549) cancer cell lines using MTT assay. IC50 values are compared with cisplatin and carboplatin, among 2 and 3, complex 2 is more potent than complex 3.

Item Type:	Article
Subjects:	Cell Biology
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	26 May 2016 08:53
Last Modified:	26 May 2016 08:53
URI:	http://nccs.sciencecentral.in/id/eprint/241

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