Gottimukkala , K.P. and Jangid, R. and Patta , I. and Sultana, D.A. and Sharma , A. and Misra-Sen , J. and Galande, S. (2016) Regulation of SATB1 during thymocyte development by TCR signaling. Mol Immunol. , 77. pp. 34-43.

Full text not available from this repository. (Request a copy)

Abstract

T lymphocyte development and differentiation is a multi-step process that begins in the thymus and completed in the periphery. Sequential development of thymocytes is dependent on T cell receptor (TCR) signaling and an array of transcription factors. In this study we show that special AT-rich binding protein 1 (SATB1), a T lineage-enriched chromatin organizer and regulator, is induced in response to TCR signaling during early thymocyte development. SATB1 expression profile coincides with T lineage commitment and upregulation of SATB1 correlates with positive selection of thymocytes. CD4 thymocytes exhibit a characteristic bimodal expression pattern that corresponds to immature and mature CD4 thymocytes. We also demonstrate that GATA3, the key transcriptional regulator of αβ T cells positively regulates SATB1 expression in thymocytes suggesting an important role for SATB1 during T cell development.

Item Type:	Article
Subjects:	Infection and Immunity
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	27 Dec 2016 07:37
Last Modified:	27 Dec 2016 07:37
URI:	http://nccs.sciencecentral.in/id/eprint/298

Actions (login required)

View Item