Clinicopathological analysis and multipronged quantitative proteomics reveal oxidative stress and cytoskeletal proteins as possible markers for severe vivax malaria.

Ray, S. and Patel , S.K. and Venkatesh, A. and Bhave, A. and Kumar, V. and Singh, V. and Chatterjee, G. and Shah, V.G. and Sharma, S. and Renu, D. and Nafis, N. and Gandhe, P. and Gogtay , N. and Thatte, U. and Sehgal , K. and Verma, S. and Karak , A. and Khanara, D. and Talukdars , A. and Kochar , S.K. and Vijeth, S.B. and Kochar, D.K. and Rojh , D. and Varma, S.G. and Gandhi, M.N. and Rapole, S. and Patankar, S. and Srivastava, S. (2016) Clinicopathological analysis and multipronged quantitative proteomics reveal oxidative stress and cytoskeletal proteins as possible markers for severe vivax malaria. Scientific Reports (6). p. 24557.

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Official URL: http://www.nature.com/articles/srep24557

Abstract

In Plasmodium vivax malaria, mechanisms that trigger transition from uncomplicated to fatal severe infections are obscure. In this multi-disciplinary study we have performed a comprehensive analysis of clinicopathological parameters and serum proteome profiles of vivax malaria patients with different severity levels of infection to investigate pathogenesis of severe malaria and identify surrogate markers of severity. Clinicopathological analysis and proteomics profiling has provided evidences for the modulation of diverse physiological pathways including oxidative stress, cytoskeletal regulation, lipid metabolism and complement cascades in severe malaria. Strikingly, unlike severe falciparum malaria the blood coagulation cascade was not found to be affected adversely in acute P. vivax infection. To the best of our knowledge, this is the first comprehensive proteomics study, which identified some possible cues for severe P. vivax infection. Our results suggest that Superoxide dismutase, Vitronectin, Titin, Apolipoprotein E, Serum amyloid A, and Haptoglobin are potential predictive markers for malaria severity.

Item Type:	Article
Subjects:	Bioinformatics and Proteomics
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	15 Dec 2016 05:29
Last Modified:	25 Feb 2021 11:45
URI:	http://nccs.sciencecentral.in/id/eprint/333

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