Singha , A.K. and Bhattacharjee , B. and Saha, D. and Maiti , D. (2017) IL-3 and GM-CSF modulate functions of splenic macrophages in ENU induced leukemia. Cytokine, 91. pp. 89-95.

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Abstract

Leukemia is often accompanied by enhanced susceptibility to infection due to compromised B cell and T cell functions. The alterations in macrophage functions in leukemia remain less investigated. Herein, we examined macrophages for their functions and responsiveness to IL-3 and GM-CSF in ENU-induced leukemia in BALB/c mice. We observed that the macrophages from the leukemic mice had less phagocytic activity, reduced chemotactic activity in response to monocyte chemoattractant protein-1(MCP-1), and decreased expression of iNOS, GM-CSF, TLR2, TLR4, IFN-γ and TNF-α. These impaired macrophage functions in leukemic mice were significantly corrected by IL-3 and GM-CSF treatment indicating the therapeutic benefit of these two cytokines in leukemia. Abbreviations IL-3, interleukin-3; GM-CSF, granulocyte macrophage-colony stimulating factor; ENU, N′-ethyl-N′-nitrosourea; NO, nitric oxide; MCP-1, monocyte chemoattractant protein-1; IFN-γ, interferon-gamma; iNOS, inducible nitric oxide synthase; TLR-2, Toll-like Receptor-2; TLR-4, Toll-like Receptor-4; TNF-α, tumor necrosis factor-α

Item Type:	Article
Subjects:	Infection and Immunity
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	24 Apr 2017 06:27
Last Modified:	24 Apr 2017 06:27
URI:	http://nccs.sciencecentral.in/id/eprint/406

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