Bhamore , J and Deshmukh , B and Haran, V and Jha , S and Singhal , R.K. and Lenka , L. and Kailasa, S.K. and Murthy, Z.V.P. (2018) One-step eco-friendly approach for the fabrication of synergistically engineered fluorescent copper nanoclusters: sensing of Hg2+ ion and cellular uptake and bioimaging properties. New Journal of Chemistry (2).

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Abstract

Herein, a single-step eco-friendly synthetic method was established for the fabrication of synergistically engineered fluorescent copper nanoclusters (Cu NCs) using curcuma root (Curcuma longa L.) extract (curcuminoids) as a template. These Cu NCs are water-soluble and emitted bright blue fluorescence under UV light illumination at 365 nm. The synergistically engineered Cu NCs exhibited an emission peak at 440 nm with quantum yield of 7.2%. Due to their optical properties, a new fluorescent analytical strategy has been developed for the sensing of Hg2+ ions and used to evaluate cellular uptake and bioimaging properties on cancer cells (RIN-5F and MDAMB231) and fungal cells (Penicillium citrinum). It was interestingly observed that Hg2+ ion effectively quenched the emission peak of Cu NCs at 440 nm, which indicates that Cu NCs act as a fluorescent sensor. Taking advantage of this, a novel fluorescent Hg2+ sensor has been established, which showed a linear range of 0.0005–25 μM with a detection limit of 0.12 nM at room temperature. Furthermore, Cu NCs exhibited good selectivity for Hg2+ against other inorganic species, and the potentiality of the method was demonstrated by detecting Hg2+ ions in water samples. Furthermore, Cu NCs act as probes for imaging of two cancer cells (RIN-5F and MDAMB231) and fungal cells (Penicillium citrinum), and the cell viability results reveals their nontoxic nature.

Item Type:	Article
Subjects:	Stem Cell Biology
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	10 Dec 2018 10:23
Last Modified:	10 Dec 2018 10:23
URI:	http://nccs.sciencecentral.in/id/eprint/524

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