Bodhale, N.P. and Pal , S. and Kumar , S. and Chattopadhyay, D. and Saha, B. and Chattopadhyay, N. and Bhattacharyya, M (2018) Inbred mouse strains differentially susceptible to Leishmaniadonovani infection differ in their immune cell metabolism. Cytokine, 112 (12).

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Abstract

Leishmania donovani is a protozoan parasite that infects mammalian macrophages, wherein the parasite resides and replicates as amastigotes, inflicting the potentially fatal disease visceral leishmaniasis. The disease is characterized by severe immunosuppression and hypocholesterolemia implying metabolic changes in L. donovani infection; whether such metabolic changes are also linked to susceptibility to the infection is not known. Herein, four inbred mouse strains were first characterized for their resistance or susceptibility profile to L. donovani infection. It was observed that these four mouse strains were differentially susceptible to L. donovani infection. Splenic expression of four key cytokines- IL-10, IL-12, IFN-γ and IL-4- revealed that the differential susceptibility of these four mouse strains to L. donovani was partially associated with these cytokines. The association was further correlated with the expression of different enzymes of the glycolytic pathway in the spleen of these L. donovani-infected mice. Thus, the observations reported here suggest an association between host metabolism, cytokine secretion profile and L. donovani susceptibility. As the chemotherapeutic choices are extremely limited and a vaccine for human use is yet to be discovered for the neglected tropical disease that is prevalent in 88 countries affecting 320 million people, this metabolic study is a significant research area that has potentials to develop a new target for anti-leishmanial chemotherapy.

Item Type:	Article
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	11 Feb 2020 04:11
Last Modified:	11 Feb 2020 04:11
URI:	http://nccs.sciencecentral.in/id/eprint/597

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