Patidar, A. and Selvaraj, S. and Sarode, A. and Chauhan, P. and Chattopadhyay, D. and Saha, B. (2018) DAMP-TLR-cytokine axis dictates the fate of tumor. Cytokine, 104. pp. 114-123.

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Abstract

Random mutations leading to loss of cell cycle control is not a rare occurrence in an organism but the mutatedcells are recognized and eliminated preventing the development of a tumor. These potentially tumorigenic cellsrelease damage-associated molecular patterns (DAMPs), which are recognized by toll-like receptors (TLRs) onmacrophages and dendritic cells. The initial TLR-DAMP interactions lead to different responses such as alteredantigen presentation and cytokine release that directly affect T cell activation and removal of the tumorigeniccells. The indirect effects of TLR-DAMP interaction include chemokine-directed altered T cell trafficking, an-giogenesis for both T cell infiltration and tumor cell metastasis, and alteration of intra-tumoral milieu con-tributing to the development of tumor cells heterogeneity. Thus, the initial TLR-DAMP interaction has a set oflocal effects that modulate tumor cell growth and heterogeneity and a disseminating set of central effects thatdynamically affect T cell trafficking and functions. Herein, we argue that the DAMP-TLR-cytokine axis in thetumor microenvironment serves as the mainstay that orchestrates and regulates the pro- and anti-tumor elementswhich dynamically interact between themselves eventuating in tumor regression or growth. The knowledge ofthis TLR-based immuno-surveillance framework is a key to developing a novel immunotherapy against cancer.

Item Type:	Article
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	13 Feb 2020 06:54
Last Modified:	13 Feb 2020 06:54
URI:	http://nccs.sciencecentral.in/id/eprint/633

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