Vyas, N.A. and Singh, S.B. and Kumbhar, A.S. and Ranade, D.S. and Walke, G.R. and Kulkarni, P.P. and Jani, V. and Sonavane, U.B. and Joshi, R.R. and Rapole, S. (2018) Acetylcholinesterase and Aβ Aggregation Inhibition by Heterometallic Ruthenium(II)-Platinum(II) Polypyridyl Complexes. Inorganic Chemistry, 57 (13). pp. 7524-7535.

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Abstract

Two heteronuclear ruthenium(II)–platinum(II) complexes [Ru(bpy)2(BPIMBp)PtCl2]2+ (3) and [Ru(phen)2(BPIMBp)PtCl2]2+ (4), where bpy = 2,2′-bipyridine, phen = 1,10-phenanthroline, and BPIMBp = 1,4′-bis[(2-pyridin-2-yl)-1H-imidazol-1-ylmethyl]-1,1′-biphenyl, have been designed and synthesized from their mononuclear precursors [Ru(bpy)2(BPIMBp)]2+ (1) and [Ru(phen)2(BPIMBp)]2+ (2) as multitarget molecules for Alzheimer’s disease (AD). The inclusion of the cis-PtCl2 moiety facilitates the covalent interaction of Ru(II) polypyridyl complexes with amyloid β (Aβ) peptide. These multifunctional complexes act as inhibitors of acetylcholinesterase (AChE), Aβ aggregation, and Cu-induced oxidative stress and protect neuronal cells against Aβ-toxicity. The study highlights the design of metal based anti-Alzheimer’s disease (AD) systems.

Item Type:	Article
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	17 Feb 2020 05:28
Last Modified:	17 Feb 2020 05:28
URI:	http://nccs.sciencecentral.in/id/eprint/657

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