Butti, R. and Kumar, T.V. and Nimma, R. and Kundu, G.C. (2018) Impact of semaphorin expression on prognostic characteristics in breast cancer. Current Topics in Medicinal Chemistry, 10. pp. 79-88.

Text 85.-1 Dr.Kundu G.C. (Breast Cancer) Review.pdf Restricted to Repository staff only Download (1900Kb) | Request a copy

Abstract

Breast cancer is one of the major causes of cancer-related deaths among women worldwide. Aberrant regulation of various growth factors, cytokines, and other proteins and their receptors in cancer cells drives the activation of various oncogenic signaling pathways that lead to cancer progression. Semaphorins are a class of proteins which are differentially expressed in various types of cancer including breast cancer. Earlier, these proteins were known to have a major function in the nerve cell adhesion, migration, and development of the central nervous system. However, their role in the regulation of several aspects of tumor progression has eventually emerged. There are over 30 genes encoding the semaphorins, which are divided into eight subclasses. It has been reported that some members of semaphorin classes are antiangiogenic and antimetastatic in nature, whereas others act as proangiogenic and prometastatic genes. Because of their differential expression and role in angiogenesis and metastasis, semaphorins emerged as one of the important prognostic factors for appraising breast cancer progression.

Item Type:	Article
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	18 Feb 2020 06:43
Last Modified:	09 Dec 2021 11:53
URI:	http://nccs.sciencecentral.in/id/eprint/675

Actions (login required)

View Item