Chanukuppa, V. and Taware, R. and Chatterjee, T. and Sharma, S. and More, T.H. and Taunk, K. and Kumar, S. and Santra, M.K. and Rapole, S. (2018) Current understanding of the potential of proteomics andmetabolomics approaches in cancer chemoresistance: A focus on Multiple Myeloma. Current Topics in Medicinal Chemistry., 18 (30). pp. 2584-2598.

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Abstract

Chemoresistance is one of the major hurdles in cancer treatment leading to recurrence of cancer and affects overall survival of patients. Cancer chemoresistance can be associated with various phenomena including modulation of vital cellular pathways. Unrevealing these alterations could provide better understanding of chemoresistance and assist in identification of new targets to overcome it. Recent advances in the field of proteomics and metabolomics have substantially helped in identification of potential targets for chemoresistance in various cancers. This review highlights the potential of proteomics and metabolomics research to explore the putative targets associated with cancer chemoresistance with a special focus on Multiple Myeloma (MM). MM is a type of hematological malignancy which constitutes about 13% of all blood cell cancers. The therapeutic advancements for MM have increased the median overall survival rate to over 3-fold in the last one and half decade. Although, in recent times significant improvements in the overall survival rate of MM is achieved, MM remains an incurable disease with unpredictable refractory mechanisms. In spite of therapeutic advances, chemoresistance thrives to be a major hurdle in the treatment of multiple myeloma which demands better understanding of chemoresitance. In this review, we have attempted to highlight the potential applications of proteomics and metabolomics research in understanding of chemoresistance in MM.

Item Type:	Article
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	18 Feb 2020 06:55
Last Modified:	18 Feb 2020 06:55
URI:	http://nccs.sciencecentral.in/id/eprint/676

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