Sagar, S. and Varankar, V and Swapnil , C. and Kamble, K and Mali , A.M. and More, M.M. and Abraham, A. and Kumar , B. and Pansare, K.J. and Narayanan, N.J. and Sen, A. and Dhake, R.D. and Joshi, A.N. and Midha, D. and Jolly, M.K. and Dong, Y. and Clements, J.A. and Bapat, S.A. (2018) Functional Balance between TCF21-Slug defines phenotypic plasticity and sub-classes in high-grade serous ovarian cancer. In: CSH. CSHL Press Springer.

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Abstract

Cellular plasticity and transitional phenotypes add to complexities of cancer metastasis initiated by single cell epithelial to mesenchymal transition or cooperative cell migration (CCM). We identified novel regulatory cross-talks between Tcf21 and Slug in mediating phenotypic and migration plasticity in high-grade serous ovarian adenocarcinoma. Live imaging discerned CCM as being achieved either through rapid cell proliferation or sheet migration. Transitional states were enriched over the rigid epithelial or mesenchymal phenotypes under conditions of environmental stresses. The Tcf21-Slug interplay identified in HGSC tumors through effective stratification of subtypes also contributed to class-switching in response to disease progression or therapy. Our study effectively provides a framework for understanding the relevance of cellular plasticity in situ as a function of two transcription factors.

Item Type:	Book Section
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	19 Feb 2020 09:01
Last Modified:	19 Feb 2020 09:01
URI:	http://nccs.sciencecentral.in/id/eprint/681

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