Jha, M.K. and Sarode, A.Y. and Saha, B. (2019) Ras isoforms selectively regulate antigen-specific immune response. Cytokine, 126.

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Abstract

H-/K-Ras and N-Ras isoforms were proposed to lack functional specificities due to similarity in 1–165 amino acids. As recent studies implied Ras isoform-specific developmental effects, we examined their functional specificity using Leishmania major infection, anti-hapten antibody response and carrier-specific T cell response. While N-Ras overexpression increased L. major infection in resistant C57BL/6 mice, H-Ras or K-Ras overexpression reduced the infection in susceptible BALB/c mice. These Ras isoforms differentially regulated anti-TNP antibody response in TNP-Ova-primed, but not in TNP-Ficoll- or TNP-LPS-primed, BALB/c mice. Ras isoform-specific silencing selectively modulated Ova-specific T cell response. The data indicate Ras isoform-specific regulation of antigen-specific immune response.

Item Type:	Article
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	24 Feb 2020 11:14
Last Modified:	24 Feb 2020 11:14
URI:	http://nccs.sciencecentral.in/id/eprint/769

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