Mistri , S and Patra , A and Mahish, MK and Saren, D and Manne, RK and Santra , MK and Zangrando, E and Puschmann , H and Manna , SC (2019) Synthesis, structure, DNA/protein binding, molecular docking and in vitro anticancer activity of two Schiff base coordinated copper(II) complexes. Polyhedron , 171. pp. 77-85.

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Abstract

Two Schiff bases HL and HL′, having potential tridentate O,N,N′ donor sets, have been used for the synthesis of two copper(II) complexes, namely [Cu(HL)(pdc)]2 (1) and [Cu(L′)2]2 (2′), where HL = 2-([2-(piperazin-yl)ethylimino]methyl)phenol, pdc = py-2,5-dicarboxylate and HL′ = 2-(((2-(di-isopropylamino)ethyl)imino)methyl)phenol. X-ray single crystal analysis of complex 1 shows a centro-symmetric dimer. It crystallizes with a number of lattice water molecules that form a network of H-bonds, also involving the protonated piperazinium fragment, giving rise to a 3D supramolecular architecture. Complex 2′ also crystallizes as dinuclear, formed through mutual bridging phenol oxygen atoms as [Cu(L′)2]2, whilst an ESI mass spectrometry study evidences that in solution the complex exists as mononuclear [Cu(L′)2] (2). The interaction of complexes 1 and 2 with calf thymus DNA (CT-DNA) and with bovine serum albumin (BSA) was investigated using electronic absorption and fluorescence spectroscopic techniques. In both studies the results show a higher binding affinity of complex 1 in comparison to 2. The anticancer activity of the complexes against human breast (MCF7) cancer cell lines reveals that complex 1 has moderate growth suppression activity against these cells with an IC50 value of 24 ± 6.24 μM.

Item Type:	Article
Subjects:	Cancer Biology
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	30 Aug 2020 08:47
Last Modified:	30 Aug 2020 08:47
URI:	http://nccs.sciencecentral.in/id/eprint/815

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