Arbade, GK and Dongardive, V and Rath, SK and Tripathi, V and Patro, UT (2020) Effect of poly(ethylene glycol) on drug delivery, antibacterial, biocompatible, physico-chemical and thermo-mechanical properties of PCL-chloramphenicol electrospun nanofiber scaffolds. International Journal of Polymeric Materials and Polymeric Biomaterials, 20.

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Abstract

The present study investigates the effect of poly(ethylene glycol) (PEG) addition on physico-chemical, thermo-mechanical, drug release, antibacterial and biocompatible properties of poly(ε-caprolactone) (PCL)-chloramphenicol (CAP) electrospun nanofiber scaffolds. Incorporation of PEG imparted enhanced hydrophilicity, crystallinity, glass transition temperature and cell growth ability and reduced cytotoxicity in PCL. In vitro drug release studies reveal that PEG addition in PCL-CAP facilitated well-defined release kinetics and the release profiles follow the Ritger–Peppas and Korsmeyer–Peppas model. The drug-loaded scaffolds showed antibacterial properties against both Gram-positive and Gram-negative bacterial strains. Further, addition of PEG significantly improved the biocompatibility of the PCL-CAP scaffolds. Graphical abstract

Item Type:	Article
Subjects:	Cell Biology
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	17 Apr 2021 13:16
Last Modified:	17 Apr 2021 13:16
URI:	http://nccs.sciencecentral.in/id/eprint/902

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