Jafarzadeh , A and Nemati , M and Chauhan , P and Patidar , A and Sarkar , A and Sharifi , I and Saha , B (2020) Interleukin-27 Functional Duality BalancesLeishmaniaInfectivity and Pathogenesis. .Frointiers in Immunolgy, 11. p. 1573.

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Abstract

IL-27 is a cytokine that exerts diverse effects on the cells of innate and adaptive immune systems. Chiefly expressed in macrophages and dendritic cells during the early phase of Leishmania infection, IL-27 contributes to the protection against L. major infection but suppresses the protective Th1 response against L. donovani, L. infantum, L. amazonensis and L. braziliensis infections, suggesting its functional duality. During the late stage of Leishmania infection, IL-27 limits the immunopathogenic reactions and tissue damages. Herein, we analyze the mechanism of the functional duality of IL-27 in the resistance or susceptibility to Leishmania infection, prompting IL-27 for anti-Leishmanial therapy.

Item Type:	Article
Subjects:	Infection and Immunity
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	28 Apr 2021 11:03
Last Modified:	29 Nov 2021 12:08
URI:	http://nccs.sciencecentral.in/id/eprint/980

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