Bhute , S and Pande, P. and Shetty , S.A. and Shelar , R. and Mane, S. and Kumbhare, S.V. and Gawali , A. and Makhani , H. and Navandar, M. and Dhotre , D. and Lubree, H. and Agarwal, D. and Patil, R. and Ozarkar , S. and Ghaskadbi, S. and Yajn , C. (2016) MolecularCharacterizationandMeta-AnalysisofGutMicrobialCommunitiesIllustrateEnrichmentofPrevotellaandMegasphaerainIndianSubjects. Frontiers in Microbiology : Microbial Symbioses (7). e660.

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Abstract

Thegutmicrobiomehasvariedimpactonthewellbeingofhumans.Itisinfluencedbydifferentfactorssuchasage,dietaryhabits,socio-economicstatus,geographiclocation,andgeneticmakeupofindividuals.Fordevisingmicrobiome-basedtherapies,itiscrucialtoidentifypopulationspecificfeaturesofthegutmicrobiome.Indianpopulationisoneofthemostethnically,culturally,andgeographicallydiverse,butthegutmicrobiomefeaturesremainlargelyunknown.ThepresentstudydescribesgutmicrobialcommunitiesofhealthyIndiansubjectsandcomparesitwiththemicrobiotafromotherpopulations.Basedonlargedifferencesinalphadiversityindices,abundanceof11bacterialphylaandindividualspecificOTUs,wereportinter-individualvariationsingutmicrobialcommunitiesofthesesubjects.WhilethegutmicrobiomeofIndiansisdifferentfromthatofAmericans,itsharedhighsimilaritytoindividualsfromtheIndiansubcontinenti.e.,Bangladeshi.DistinctivefeatureofIndiangutmicrobiotaisthepredominanceofgenusPrevotellaandMegasphaera.Further,whencomparedwithothernon-humanprimates,itappearsthatIndianssharemoreOTUswithomnivorousmammals.Ourmetagenomicimputationindicateshigherpotentialforglycanbiosynthesisandxenobioticmetabolisminthesesubjects.OurstudyindicatesurgentneedofidentificationofpopulationspecificmicrobiomebiomarkersofIndiansubpopulationstohavemoreholisticviewoftheIndiangutmicrobiomeanditshealthimplications.

Item Type:	Article
Additional Information:	This is Open access article for full text click above weblink
Subjects:	Insect Molecular Biology
Depositing User:	Mr. Rameshwar Nema
Date Deposited:	25 May 2016 04:52
Last Modified:	25 May 2016 04:53
URI:	http://nccs.sciencecentral.in/id/eprint/240

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